The COVID-19 pandemic is resulting in widespread and ongoing changes to how the K–12 education system functions, including disruptions to science teaching and learning environments. In early September, 2020, the Board on Science Education at the National Academies of Sciences, Engineering, and Medicine released Teaching Science During the COVID-19 Pandemic, to offer guidance to science educators as they take on the challenge of adapting instruction to these challenging times. The guide aims to describe what high quality science and engineering education can look like in a time of great uncertainty and to support practitioners as they work toward their goals. This session will provide an overview of the key principles in the guide and engage participants in a discussion of how these principles can guide the difficult decisions they are making day to day as they navigate complex blends of virtual and in-person learning environments.​